DISPARITY BETWEEN THE EFFECT OF GLUCOSE AND ARGININE ON INSULIN RELEASE FROM THE PERFUSED PANCREAS OF RATS WITH NON-INSULIN DEPENDENT DIABETES

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 293  (10) , 601-+
Abstract
Insulin secretion was evaluated with the isolated perfused pancreas in a rat model of non insulin-dependent diabetes (type II diabetes). In the diabetic rats, pancreatic insulin stores were twice as low as in the controls. The amount of insulin release was expressed as a percentage of the insulin content in each pancreas. With perfusate glucose at 5.5 mM, the basal insulin secretion in the diabetics was not significantly different from that in the controls. With perfusate glucose at 16.2 mM the diabetic pancreases exhibited 2 distinct patterns of response: in some rats the insulin output expressed as a percentage of the insulin content of the pancreas was not different from the controls, while in the others there was no response to glucose. By contrast, with arginine (19.2 mM) the response was decreased to the same extent in all the diabetics. Thus some diabetic rats exhibit a selective functional defect concerning the response to glucose contrasting with the preservation of the basal insulin release and of the response to arginine.

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