Induction in vitro of Microtubular Crystals by Vinca Alkaloids
- 1 August 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 165 (3892) , 495-496
- https://doi.org/10.1126/science.165.3892.495
Abstract
The addition of vinblastine or vincristine to solutions of pure microtubule protein or to supernatants from high-speed centrifugation of rabbit-brain homogenates results in the formation of a fine precipitate. Examination of this precipitate by electron microscopy reveals ordered structures with areas of ladder-like configuration.Keywords
This publication has 8 references indexed in Scilit:
- Vinblastine-Induced Precipitation of Microtubule ProteinScience, 1969
- MICROTUBULAR CRYSTALS IN MAMMALIAN CELLSThe Journal of cell biology, 1969
- Colchicine-binding protein of mammalian brain and its relation to microtubulesBiochemistry, 1968
- ULTRASTURCTURE OF CENTERAL NERVOUS SYSTEM LESIONS IN METACHROMATIC LEUKKODYSTROPHY WITH SPECIAL REFERENCE TO MORPHOGENESISJournal of Neuropathology and Experimental Neurology, 1968
- EFFECTS OF MITOTIC SPINDLE INHIBITORS ON NEUROTUBULES AND NEUROFILAMENTS IN ANTERIOR HORN CELLSThe Journal of cell biology, 1968
- Microtubule Crystals: A New Biophysical Phenomenon induced by Vinca AlkaloidsNature, 1968
- STUDIES ON THE MICROTUBULES IN HELIOZOAThe Journal of cell biology, 1967
- HISTOCHEMICAL AND ULTRASTRUCTURAL STUDIES ON HELA CELL CULTURES EXPOSED TO SPINDLE INHIBITORS WITH SPECIAL REFERENCE TO THE INTERPHASE CELLJournal of Histochemistry & Cytochemistry, 1964