Hyperemesis Gravidarum

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Abstract
Liver function tests were performed on 103 women with hyperemesis gravidarum. In the 57 patients with symptoms manageable in a complications clinic, the results of the liver tests were comparable to those found in women with normal pregnancies. An occasional patient had sulfobromoph-thalein (BSP) retention greater than 10%. Hyperemesis was severe enough to warrant hospitalization of 46 women. Liver test results were frequently abnormal in this group. BSP retention greater than 10% was found in 60% of the patients, mild hyperbilirubinemia in 1/3, and modest elevations of serum glutamic oxalacetic transaminase (SGOT) in 1/4. Abnormal thymol turbidity or cephajtn flocculation test results were not observed in the women with either elevated serum bilirubin or SGOT, or both. Needle biopsies of the liver in 4 patients were normal. Alterations in the above tests are felt to be due to malnutrition. Differentiation of patients with hyperemesis gravidarum from pregnant women with viral hepatitis is discussed.

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