Susceptibility of Tumor Cells in Different Phases of the Mitotic Cycle to the Effect of Immune Lymphocytes

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Abstract
The cytotoxic effect of immune lymphocytes against synchronized L cells was studied. This effect occurred after the addition of immune lymphocytes to the target cells only at the beginning of the G1 phase. Target cells in the early G1 phase were destroyed during 30 minutes of interaction with immune lymphocytes. The addition of immune lymphocytes to the target cells 3 hours after the beginning of the G1 phase, as well as their addition to the target cells in the S, G2, and M phases, induced cytotoxicity neither during 30 minutes nor throughout any of these phases. The addition of immune lymphocytes to the synchronized target cells in all phases of the mitotic cycle, except the early G1 phase, led to the same cytotoxic effect as in the unsynchronized L cells. The high susceptibility of the early G1 phase to the effect of immune lymphocytes showed a special physiologic state of cells in this phase, designated as G1/α. It is assumed that the cytotoxic effect of immune lymphocytes against unsynchronized L cells is easily detected after 48 hours and depends on the passage of each cell through the G1/α phase in contact with immune iymphocytes.

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