A STUDY OF CHEMICAL CARCINOGENESIS .79. TUMORIGENICITY OF 5-METHYLCHRYSENE DIHYDRODIOLS AND DIHYDRODIOL EPOXIDES IN NEWBORN MICE AND ON MOUSE SKIN

  • 1 January 1985
    • journal article
    • research article
    • Vol. 45  (4) , 1449-1452
Abstract
5-Methylchrysene, (.+-.)-trans-1,2-dihydro-1,2-dihydroxy-5-methylchrysene, (.+-.)-trans-7,8-dihydro-7,8-dihydroxy-5-methylchrysene, (.+-.)-trans-1,2-dihydroxy-anti-3,4-epoxy-1,2,3-4-tetrahydro-5-methylchrysene (anti-DE-l), (.+-.)-trans-1,2-dihydroxy-syn-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (syn-DE-l) and (.+-.)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydro-5-methylchrysene (anti-DE-II) were tested for tumorigenicity in newborn mice and for tumor-initiating activity on mouse skin. In newborn mice, a total dose of 56 nmol of anti-DE-I induced 4.6 lung tumors/mouse and 1.2 liver tumors/mouse. These incidences were significantly higher than observed for any of the other metabolites, tested at equimolar doses. Anti-DE-l, but not syn-DE-l or anti-DE-ll, is a major ultimate carcinogen of 5-methylchrysene in the newborn mouse. Anti-DE-l was also more tumorigenic than anti-DE-ll on mouse skin, inducing 4.4 tumors/mouse after an initiating dose of 100 nmol, compared to zero tumors per mouse induced by anti-DE-ll. However, anti-DE-I was less tumorigenic on mouse skin than was its metabolic precursor, trans-1,2-dihydro-1,2-dihydroxy-5-methylchrysene, or its parent hydrocarbon, 5-methylchrysene.

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