SEPARATION OF GROWTH-PROMOTING HORMONE FROM THAT INDUCING PREMATURE ESTRUS IN THE ANTERIOR PITUITARY GLAND

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Abstract
It is difficult to begin any article on the pituitary gland without a reference to the work of Harvey Cushing, who, directly through his own work and indirectly through the enthusiasm which he has inspired in his pupils, has done more than any other man to unravel that small organ's secrets. As regards the anterior lobe, it was he who first showed clearly that its subtotal removal led to a cessation of growth in young animals and an atrophy of the genitalia in mature ones.1 His results were strikingly confirmed and extended by Aschner,2 Blair Bell3 and others, and most recently by Smith,4 whose studies of the results of hypophysectomy in the rat leave little work for future investigators in this field. They have been confirmed by unpublished experiments, both in dogs and in rats, in the Surgical Research Laboratory. ACCELERATION OF GROWTH BY ADMINISTRATION OF