9-Aminoacridine mutagenesis of bacteriophage T4 intracellular DNA
- 1 December 1975
- journal article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 138 (4) , 333-343
- https://doi.org/10.1007/bf00264803
Abstract
Most of the intracellular T4 DNA made in the presence of 9-aminoacridine is of lower molecular weight than mature T4 DNA and does not get packaged into phage particles. Using a T4 DNA transformation assay, we have examined this intracellular T4 DNA for its content of 9-aminoacridine-induced revertants of certain rII gene frameshift mutations. The proportion of acridine-induced revertants in the intracellular DNA population is close to that found in the phage progeny made in the presence of 9-aminoacridine. Thus, the generation of low molecular weight T4 DNA in the presence of 9-aminoacridine is not, in itself, also a mutagenic process.Keywords
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