Effects of flavonoids and related compounds from mulberry tree on arachidonate metabolism in rat platelet homogenates.
- 1 January 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (3) , 1223-1227
- https://doi.org/10.1248/cpb.34.1223
Abstract
The effects of various flavonoids and related compounds isolated from the root bark of mulberry tree on a rat platelet lipoxygenase and cyclooxygenase products formed from [1-14C]arachidonic acid were studied. Morusin was found to inhibit the formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products) more strongly than the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product). Oxydihydromorusin and kuwanon C were also found to inhibit the formation of thromboxane B2 more strongly than the formations of HHT and 12-HETE. Mulberrofuran A inhibited the formations of HHT and thromboxane B2, but it increased the formation of 12-HETE. Albanol B and mulberrofuran F did not affect arachidonate metabolism in rat platelet homogenates.This publication has 1 reference indexed in Scilit:
- Selective inhibition of platelet lipoxygenase by baicaleinBiochemical and Biophysical Research Communications, 1982