Antineoplastic agents. Part 395.1 Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp.
- 1 January 1999
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 10,p. 915-916
- https://doi.org/10.1039/a902380a
Abstract
A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge Agelas sp. led to isolation of a trace (7.42 × 10–6% yield) cancer cell growth inhibitor (lung NCI-H460 GI50 0.77 µg m–1 to ovary OVCAR-3 GI50 2.8 µg ml–1) designated agelagalastatin 6; it is the first example of a natural product containing a digalactofuranosyl unit.Keywords
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