Abstract
The conventional sequence of stressful event (stressor) causing stress (biochemical and physiological changes) which, in turn, causes pathological consequences (diseases) is examined. A number of experiments are described which show that biochemical, physiological and/or pathological changes in an organism do not seem to be caused by the aversive or noxious nature of the stressor but by the ability or inability of the organism to deal with this stressor. If an individual can cope successfully with the environmental challenge, little or no stress is experienced, the challenge is viewed as only minimal stressful and no major health consequences seem to arise. If an individual cannot cope or needs a great deal of effort to cope, stress is experienced, the environmental event becomes stressful and major health consequences seem to arise. Thus, coping strategies available to and employed by an individual will determine whether or not stress is experienced, whether or not an event becomes stressful and whether or not pathological consequences will occur.