Pre- and post-treatment distribution pattern of 123I-MIBG in patients with phaeochromocytomas and paragangliomas

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Abstract
1231-metaiodobenzylguanidine (MIBG) localizes in adrenergic neurones. A comparison of YO washout of MIBG, during two time intervals, from various organs was carried out in seven normal volunteers and 11 patients with phaeochromocytoma andlor paraganglioma pre- and post-treatment using MIBG. YO washout of MIBG during the time intervals of 30 min to 4 h were as follows: heart, controls 26.1k3.8 u. patients 51.5k9.1, (p < 0.001), lungs, cont'rols 36.5k5.3 u. patients 47.3k5.8, (p < 0.05), liver, controls 26.5k5.7 u. patients 53.4k12.0 (p < 0.01). Following treatment the YO washout of MIBG from these tissues between 30 min and 4 h were similar in both groups of subjects, This observation coincided with the normalization of plasma catecholamine levels in most of the treatment group. There was no significant difference between the treatment and control groups, in the YO washout of MIBG from these tissues during the 4 h and 22 h time intervals either before or after treatment. We conclude that quantitative scintigraphy 30 min to 4 h after MIBG administration is a useful technique to evaluate the pathophysiological effects of high circulating catecholamines in patients with phaeochromocytomas and/or paragangliomas.

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