The modulation of histamine release by alpha-Adrenoceptors: Evidences in murine neoplastic mast cells
- 1 March 1977
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 7 (1) , 57-61
- https://doi.org/10.1007/bf01964881
Abstract
Murine neoplastic mast cells which have been loaded with exogenous labelled histamine, released14C-histamine when exposed to increasing concentrations of phenylephrine and noradrenaline. Adrenaline was only slightly effective, while isoprenaline and dibutyryl-cyclic-AMP were fully inactive. The release of histamine evoked by alpha-adrenergic agonists was antagonized by phentolamine, and left unchanged by practolol and cocaine. It is concluded that alpha-adrenoceptors may be valuable in evoking histamine release by murine neoplastic mast cells.Keywords
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