RU 486 Reduces Morphine-Induced Analgesia in Mice, but Steroid Receptors Are Not Involved
- 1 January 1996
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 52 (6) , 387-391
- https://doi.org/10.1159/000139406
Abstract
The effects of subcutaneous pretreatment with the glucocorticoid/progesterone receptor antagonist RU 486 on the antinociceptive action of peripherally administered morphine were evaluated by the hot-plate test in mice. The steroid significantly reduced the analgesic effect of the opiate. Neither dexamethasone nor progesterone modified the effects of RU 486 on morphine-induced analgesia. Therefore, the present data indicate that the modulatory effect of RU 486 on morphine-induced analgesia does not involve the binding of this drug to classical steroid receptors.Keywords
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