Heterogeneity of Human Amyloid Protein AA and Its Related Serum Protein, SAA
- 1 January 1983
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 17 (1) , 83-88
- https://doi.org/10.1111/j.1365-3083.1983.tb00768.x
Abstract
The heterogeneity of the human amyloid proteins SAA and AA was studied. Both proteins could be separated into several fractions by ion-exchange chromatograpby. Amino acid analysis of the ion-exchange-chromatographed fractions of protein AA showed that the main difference was in the length of the polypeptide. Thus, it seems that the original AA preparation consists of a mixture of AA proteins with length ranging from 66 to 78 amino acid residues. By enzymatic degradation of three different forms of SAA with kallikrein, fragments were formed with a molecular weight very similar to thai of protein AA.Keywords
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