Production of Antibody to Tetanus Toxoid by Continuous Human Lymphoblastoid Cell Lines
- 31 March 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4336) , 1439-1441
- https://doi.org/10.1126/science.204013
Abstract
Peripheral lymphocytes from human volunteers boosted with tetanus toxoid were cultured after in vitro infection with Epstein-Barr virus. Forty-four continuous lymphoblastoid lines were established which continued to secrete human gamma globulin; seven of these secreted antibody to tetanus toxoid. Subcultures derived from limiting dilution experiments continued to secrete the antibody. Some of these antibody-secreting cells have been in continuous culture for more than 6 months.This publication has 23 references indexed in Scilit:
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