On the Structure of the Luteinizing Hormone/Chorionic Gonadotropin Receptor*

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Abstract
DURING the past 15 yr, different techniques have been used to examine the structure of the mammalian LH/CG receptor. Although all investigators agree that in the cell membrane this receptor is an oligomeric structure, there is no consensus on the number of subunits, their molecular weights, or on the nature of the bonds that hold these subunits together. In this review we will 1) compile, compare, and contrast the data presented to support the conflicting structures that have been proposed for this receptor; 2) attempt to point out the strengths and weaknesses of the methods and of the data used to derive these different proposals; and 3) attempt to reconcile the seemingly conflicting results obtained by different groups. When possible, we will also try to compare our knowledge of the LH/CG receptor with what is known about the properties and structures of the receptors for two other homologous hormones (FSH and TSH).

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