Tumour necrosis factor-α gene haplotype is associated with pre-eclampsia

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Abstract
We determined whether polymorphisms in the promoter region of the tumour necrosis factor alpha (TNF-α) gene contributes to differences in susceptibility to develop pre-eclampsia. The study involved 133 pre-eclamptic and 115 healthy pregnant women who were genotyped for the G-308A polymorphism of the TNF-α gene. The frequency of the G-308A allele was more common in the pre-eclampsia group than among the controls (P=0.046), giving an odds ratio of 0.57 (95% CI: 0.32–0.99), but there were no differences in the genotype distribution. The data from the G-308A polymorphism was combined with the previously published genotype and allele data from the C-850T polymorphism of the TNF-α gene, and used to assess a haplotype estimation analysis. Estimated overall pair of loci haplotype frequencies differed significantly between the groups (P=0.023±0.004). In the single haplotype association analysis, the haplotype C-A versus others was over-represented in the pre-eclampsia group (P=0.041±0.003), whereas the haplotype T-G versus others was less common in the pre-eclampsia group (P=0.035±0.003), compared with the controls. In conclusion, the polymorphisms of the TNF-α gene showed a significant haplotype association with susceptibility to pre-eclampsia in the Finnish population.

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