Mechanism of action of collagenase on the blood-brain barrier permeability. Increase of endothelial cell pinocytotic activity as shown with horse-radish peroxidase as a tracer
- 1 December 1979
- journal article
- Published by Wiley in Cell Biology International Reports
- Vol. 3 (9) , 747-751
- https://doi.org/10.1016/0309-1651(79)90080-8
Abstract
The ultrastructural mechanism of the protease induced blood-brain barrier permeability-increase was studied with horse-radish peroxidase as a tracer. After intravenous injection of collagenase or pronase, a significantly increased number of pinocytotic vesicles was found in brain capillary endothelial cells. alpha-Chymotrypsine did not exert such an action.Keywords
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