Risk ranges for various endpoints following exposure to 2,3,7,8-TCDD
- 1 April 2000
- journal article
- review article
- Published by Taylor & Francis in Food Additives & Contaminants
- Vol. 17 (4) , 335-346
- https://doi.org/10.1080/026520300283405
Abstract
Conducting a dose-response analysis for an environmental contaminant requires a careful evaluation of most of the available data focusing on both the magnitude of the effect and the possible ranges of dose-response shapes which fit the data. This paper calculates potency values (1% response exposures) for human and animal data on cancer, non-cancer and biological effect endpoints for TCDD and finds that a reasonable estimate for 1% excess cancer would be between 1 and 50 pg/kg/day. The paper also evaluates the adequacy of linear and non-linear models for fitting these data and concludes that the assumption of a threshold dose-response is not fully supported by these data.Keywords
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