Interstitial Pneumonitis Associated with Azathioprine Therapy

Open Access

1 February 1978

journal article
research article
Published by Oxford University Press (OUP) in American Journal of Clinical Pathology

Vol. 69 (2) , 181-185
https://doi.org/10.1093/ajcp/69.2.181

Abstract

Weisenburger, Dennis D.: Interstitial pneumonitis associated with azathioprine therapy. Am J Clin Pathol 69:181–185, 1978. A 24-year-old female patient with rapidly progressive renal failure secondary to membrano-proliferative glomerulonephritis is thought to have subsequently had acute interstitial pneumonitis as a consequence of azathioprine therapy. The occurrence of the pulmonary injury coincided with the rapid onset of severe renal failure and was reversible with cessation of the drug. Accumulation of toxic metabolic products of azathioprine with subsequent injury to the pulmonary interstitium is suggested as the etiology. Azathioprine should be considered in the differential diagnosis of interstitial pneumonitis in all patients taking the drug.

Keywords

This publication has 1 reference indexed in Scilit:

Drugs Five Years Later
Annals of Internal Medicine, 1973