AN INDIRECT SYMPATHOMIMETIC EFFECT OF BURIMAMIDE ON KITTEN ISOLATED ATRIA

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Abstract
Burimamide (34‐1080 μM) caused a concentration‐dependent increase in the force and frequency of contraction of kitten isolated atria. Metiamide (467 μM) had no stimulant action on kitten atria and did not modify the effects of burimamide. The atrial stimulation produced by burimamide was reduced by (‐)‐propranolol (34‐68 nM) and by cocaine (3 μM). The atrial stimulant effect of burimamide was prevented by pretreatment of kittens with reserpine (1 mg/kg, 24 h before the experiment). It is concluded that burimamide causes atrial stimulation by releasing catecholamines.