Creatol (5-hydroxycreatinine), a new toxin candidate in uremic patients
- 1 May 1990
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 46 (5) , 470-472
- https://doi.org/10.1007/bf01954234
Abstract
Summary Both 5-hydroxy-1-methylhydantoin (3) and the hitherto unrecognized 5-hydroxycreatinine (2-amino-5-hydroxy-1-methyl-imidazol-4(5H)-one or creatol) (6) can be isolated from the urine of uremic patients, in whom these compounds probably arise as oxidative metabolites of creatinine (1). The enhanced production of the well-known uremic toxin, methylguanidine (8), from creatinine (1) in such patients, almost certainly occurs via the newly recognized metabolite (6).Keywords
This publication has 12 references indexed in Scilit:
- Comparison of Toxic Effects of Methylguanidine, Guanidinosuccinic Acid and Creatinine in Rats with Adenine-Induced Chronic Renal FailureNephron, 1989
- The stepwise mammalian oxidation of the hydantoin 1-methylimidazolidine-2,4-dione into methylimidazolidinetrione via 5-hydroxy-1- methylimidazolidine-2,4-dioneJournal of the Chemical Society, Perkin Transactions 1, 1989
- The metabolism of 1-methylhydantoin via 5-hydroxy-1-methylhydation in mammalsBiochimica et Biophysica Acta (BBA) - General Subjects, 1988
- Bioactive compounds produced in animal tissues (II); Two hydantoin plant growth regulators isolated from inflamed rabbit skin tissueTetrahedron Letters, 1987
- Animal Model of Adenine-Induced Chronic Renal Failure in RatsNephron, 1986
- Biosynthesis of Methylguanidine in Isolated Rat Hepatocytes and in vivoNephron, 1985
- Evidence of Red Blood Cell Membrane Lipid Peroxidation in Haemodialysis PatientsNephron, 1984
- Methylguanidine in UremiaArchives of internal medicine (1960), 1973
- Uraemia-like syndrome in dogs chronically intoxicated with methylguanidine and creatinine.1969
- Bacterial degradation of creatinineBiochimica et Biophysica Acta, 1958