Bone resorption and Ca45 turnover in growing rats

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Abstract
A group of rats were maintained on a Ca45 diet for 21 days, then sacrificed at varying time intervals after substituting a nonradioactive diet. The total calcium and calcium specific activity of several bones, blood and urine were determined. After correcting for the dilution of radioactivity due to an increase in total bone calcium, it was found that there was little, if any, loss of Ca45 from rapidly growing bones. When the growth of the bone decreased, a small measurable loss was detected. It was assumed this slow loss of Ca45 represented bone resorption. Values for the rate of bone resorption (replacement rates) are presented and their significance in the growth of the bone discussed.