Room-temperature phosphorimetric method for the determination of the drug naphazoline in pharmaceutical preparations
- 1 January 1998
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 123 (5) , 1069-1071
- https://doi.org/10.1039/a708672e
Abstract
A selective and sensitive micelle-stabilized room-temperature phosphorimetric (MS-RTP) method for the determination of naphazoline in pharmaceutical preparations is described. The method is based on obtaining a phosphorescence signal from naphazoline using a micellar agent (sodium dodecyl sulfate), a heavy atom salt (TlNO3) and a deoxygenation agent (Na2SO3). Optimization of the various conditions permitted the establishment of an MS-RTP method for naphazoline determination with a detection limit of 64.2 ng ml–1 and a relative standard deviation of 3.74% at the 500 ng ml–1 level. The method was applied to the analysis of pharmaceutical preparations.Keywords
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