Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens
- 1 December 1997
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 41 (12) , 2776-2780
- https://doi.org/10.1128/aac.41.12.2776
Abstract
Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.Keywords
This publication has 38 references indexed in Scilit:
- Herpes simplex virus recombination vectors designed to allow insertion of modified promoters into transcriptionally “neutral” segments of the viral genomeVirus Genes, 1995
- Molecular mimicry and Chlamydia trachomatis infection of eukaryotic cellsTrends in Microbiology, 1994
- The inhibitory effect of supermicidal agents on replication of HSV-2 and HIV-1 in-vitroJournal of Antimicrobial Chemotherapy, 1993
- Barrier contraceptive use and HIV infection among high-risk women in CameroonAIDS, 1993
- Cell-Surface Heparan Sulfate Proteoglycan Mediates HIV-1 Infection of T-Cell LinesAIDS Research and Human Retroviruses, 1993
- Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans.The Journal of cell biology, 1992
- Chlamydia trachomatis infection of human fallopian tube organ culturesJournal of General Microbiology, 1990
- Activity of Dextran Sulfate and Other Polyanionic Polysaccharides Against Human Immunodeficiency VirusThe Journal of Infectious Diseases, 1988
- Distal Tubal Obstruction Induced by Repeated Chlamydia trachomatis Salpingeal Infections in Pig-Tailed MacaquesThe Journal of Infectious Diseases, 1987
- Suramin Protection of T Cells in Vitro Against Infectivity and Cytopathic Effect of HTLV-IIIScience, 1984