Genetic control of lymphocyte suppression. I. Lack of suppression in aged NZB mice is due to a B cell defect.

  • 1 December 1978
    • journal article
    • Vol. 121  (6) , 2241-3
Abstract
Con A-activated cells from old NZB mice were found capable of inhibiting the polyclonal response of cells from young NZB and BALB/c animals. Furthermore, Con A-preactivated spleen cells from young NZB and BALB/c mice did not significantly affect the response of spleen cells from old NZB mice. These results suggest that the defective suppressive activity in old NZB mice may be traced to a defect at the B cell level.

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