THE INCREASINGLY numerous recent reports regarding the usefulness of pituitary adrenocorticotropic hormone (corticotropin) and of cortisone in the treatment of a wide variety of diseases1 would indicate that these substances are to become important therapeutic agents. Because of the comparatively short time which has elapsed since the introduction of these agents for clinical study, and because of the relatively small number of patients about whom observations have been published, the therapeutic scope and limitations of these forms of therapy have not yet been completely defined. The purpose of this report is the presentation of the results obtained and side effects observed in the course of treatment of a variety of diseases in a comparatively large series of patients who received two preparations of corticotropin which are different from the preparation used in the majority of published clinical studies. A preliminary report on 42 patients has appeared,2 and detailed