Effect of piperidine on benzylaspartyl peptides in solution and in the solid phase
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 9,p. 505-507
- https://doi.org/10.1039/c39830000505
Abstract
Basic conditions (e.g. piperidinolysis), used for the removal of the Nα-9-fluorenylmethyloxycarbonyl group, lead to significant cleavage of side-chain benzyl esters of peptides containing benzylaspartyl residues both in solution and solid-phase syntheses; the intermediate imide derivative is slowly transformed to a mixture of piperidides.Keywords
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