In vivo effects of the 5‐HT6 antagonist SB‐271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5‐HT, glutamate and aspartate
- 1 May 2000
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 130 (1) , 23-26
- https://doi.org/10.1038/sj.bjp.0703288
Abstract
Although the 5‐HT6 receptor subtype was identified some 5 years ago, very little is known about its function within the brain. Here we demonstrate, for the first time, the neurochemical effects of a selective 5‐HT6 receptor ligand. Using in vivo microdialysis in the freely moving rat, we evaluated the effects of the selective 5‐HT6 receptor antagonist SB‐271046 by simultaneous measurement of 5‐hydroxytryptamine (5‐HT), dopamine (DA), noradrenaline (NA), glutamate and aspartate from the striatum and frontal cortex. SB‐271046 did not alter basal levels of 5‐HT, DA and NA in either brain region. Similarly, there was no change basal levels of either of the excitatory amino acids within the striatum. In contrast, administration of SB‐271046 (10 mg kg−1 s.c.) produced a significant (PBritish Journal of Pharmacology (2000) 130, 23–26; doi:10.1038/sj.bjp.0703288Keywords
This publication has 18 references indexed in Scilit:
- 5-HT6 RECEPTORSBehavioural Pharmacology, 1999
- The role of the anterior prefrontal cortex in human cognitionNature, 1999
- Investigation of stretching behaviour induced by the selective 5‐HT6 receptor antagonist, Ro 04–6790, in ratsBritish Journal of Pharmacology, 1999
- 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): A Potent, Selective, and Orally Bioavailable 5-HT6 Receptor AntagonistJournal of Medicinal Chemistry, 1999
- Involvement of 5‐HT6 receptors in nigro‐striatal function in rodentsBritish Journal of Pharmacology, 1998
- The Cerebral Cortex and Parafascicular Thalamic Nucleus Facilitate In vivo Acetylcholine Release in the Rat Striatum through Distinct Glutamate Receptor SubtypesEuropean Journal of Neuroscience, 1996
- Neurophysiological correlates of improvements in cognitive characteristics in monkeys during modification of NMDA-ergic structures of the prefrontal cortexNeuroscience and Behavioral Physiology, 1996
- Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistryNeuroscience, 1995
- A Novel Rat Serotonin (5-HT6) Receptor: Molecular Cloning, Localization and Stimulation of cAMP AccumulationBiochemical and Biophysical Research Communications, 1993
- Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious ratsNeuroscience Letters, 1993