ANTIGENIC ASSOCIATION BETWEEN KIDNEY AND THYMOCYTE

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Abstract
Commonly shared antigens between the renal tissue and lymphocytes, especially the thymocyte were studied in rats by immunofluorescence. To clarify the specificity of antisera, absorption analysis was carried out. The brain-associated thymocyte antigen, presumably Thy 1 antigen, was detected by anti-rat thymocyte serum or anti-rat brain serum not only on the surface of thymocytes but also in renal glomeruli. Distribution or localization of the antigen in glomeruli was considerably different between acetone-fixed and unfixed kidney sections. On the fixed section the antigen was shown exclusively in the glomerular mesangium. It appeared to be diffusely dispersed on glomerular tissue on the unfixed section. Antisera against kidney-related antigens, anti-Fx1A [anti-rat brush border serum], anti-GBM [anti-rat glomerular basement membrane serum] and anti-CIG [anti-bovine cold insoluble globulin serum] did not react with the surface of thymocytes, or they were not absorbed with brain homogenate.