Immunoglobulin V Genes in Reed–Sternberg Cells
- 8 February 1996
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 334 (6) , 404-406
- https://doi.org/10.1056/nejm199602083340615
Abstract
Hummel et al. (Oct. 5 issue)1 report the polyclonality of Reed–Sternberg cells in 6 of 12 cases of Hodgkin's disease. In three other cases, there were mixed polyclonal and monoclonal populations of Reed–Sternberg cells, and in three cases the cells were monoclonal. We are concerned about the reported results of this study.Keywords
This publication has 9 references indexed in Scilit:
- Hodgkin's Disease with Monoclonal and Polyclonal Populations of Reed–Sternberg CellsNew England Journal of Medicine, 1995
- Numerical chromosome aberrations are present within the CD30+ Hodgkin and Reed-Sternberg cells in 100% of analyzed cases of Hodgkin's disease [see comments]Blood, 1995
- Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.Proceedings of the National Academy of Sciences, 1994
- The cellular biology of the Reed-Sternberg cell [see comments]Blood, 1994
- Detection of immunoglobulin heavy-chain gene rearrangement at the single-cell level in malignant lymphomas: No rearrangement is found in hodgkin and reed-sternberg cellsInternational Journal of Cancer, 1994
- Detection of Epstein-Barr Virus DNA in Hodgkin- and Reed-Sternberg-Cells by Single Cell PCRLeukemia & Lymphoma, 1994
- Single-cell analysis of Hodgkin and Reed-Sternberg cells: molecular heterogeneity of gene expression and p53 mutationsBlood, 1993
- The immunophenotype of reed-sternberg cells. A study of 50 cases of Hodgkin' disease using fixed frozen tissuesCancer, 1989
- Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cellsNature, 1982