Atomic Absorption Determination of Certain Sulfonamides via Their Metal Complexes

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Abstract
An atomic absorption spectroscopic method for microdetermination of sulfathiazole, sulfadiazine and sulfamerazine was developed. The procedure is based upon the measurement of the metal content of the metal chelate. The experimental conditions and the molar ratios were thoroughly studied. The percentage recoveries for the 3 compounds tested were 99.5 .+-. 1.30, 99.7 .+-. 0.80 and 100.6 .+-. 0.78, respectively. The proposed method was applied to some common pharmaceutical preparations; the results were satisfactory and in good agreement with those given by complexometric and diazometric methods.