Some Aspects of the Growth of Proteus vulgaris with Limiting Concentrations of Nicotinic Acid

Abstract
P. vulgaris growth in a simple defined medium with limiting concns. of nicotinic acid as measured, the detns. continuing for several hrs. after the disappearance of all detectable nicotinic acid from the medium. A linear phase of protoplasmic synthesis and of O2 uptake follows this disappearance and lasts for 2.5-3 hrs., while the amt. of recoverable nicotinic acid in the cells remains constant. It is suggested that, during the period of linear growth, the rate of protoplasmic synthesis is detd. by the presence within the total cell population of a more or less constant amt. of nicotinic acid or its active derivatives.

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