Die Ultrastruktur der Dyskeratose bei invasivem Larynxkarzinom*

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Abstract
The occurrence and morphology of dyskeratotic cells in squamous cell carcinoma of the larynx [in humans] was examined by EM. An aggregation and condensation of cytoplasmic tonofilaments was observed in the dyskeratotic cells. The remnants of nuclei and other degenerated organelles were intermingled with electron dense tonofilaments aggregates. In some dyskeratotic cells whole desmosomes or fragmented desmosomal structures were located within the cytoplasm. The more advanced dyskeratotic cells were phagocytized by the surrounding malignant keratinocytes in toto or in fragments. The dyskeratosis in laryngeal carcinoma is characterized by premature, abnormal and individual keratinization of the malignant keratinocytes.

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