EXPERIMENTAL-INFECTION OF THE MARMOSET GENITAL-TRACT WITH CHLAMYDIA-TRACHOMATIS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 61  (3) , 291-295
Abstract
A strain of C. trachomatis isolated in McCoy (human synovial cell) cells from the urethra of a patient suffering from non-gonococcal urethritis was inoculated into the vagina of 8 female marmosets. Chlamydiae were isolated repeatedly for 10-42 days from the lower genital tract of 7 of the marmosets. Of the infected animals, 6 developed an acute inflammatory reaction in the genital tract and chlamydial inclusions in epithelial cells were seen in smears from 2 of them. Each of 6 infected marmosets examined developed humoral antibodies to C. trachomatis. Three control animals inoculated intravaginally with chlamydia-free McCoy cells showed no evidence of chlamydial infection. Since the marmoset is small and easily bred in captivity, it should provide a useful model for studying the mechanisms of chlamydial pathogenicity.

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