Determinants of fasting plasma triglyceride levels: metabolism of hepatic and intestinal lipoproteins

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Abstract
The contribution of the kinetics of exogen‐eous and endogenous lipoproteins in determining the level of triglyceride in fasting plasma was assessed in a group of 19 normolipidaemic and hypertriglyceridae‐mic subjects. From data derived during a 9‐h infusion of [15N]‐glycine, we have assessed very low density lipoprotein apolipoprotein B production, and from data analysed by kinetic modelling obtained following ingestion of retinol and triolein, we have assessed chylomicron and chylomicron remnant clearance in a group of 19 normolipidaemic and hypertriglyceridae‐mic subjects. A strong positive correlation was observed between the fasting plasma triglyceride level and the reciprocal of the apolipoprotein B fractional synthetic rate (r= 0.83, Pf 20–400; r= 0.87, Pf400; r= 0.69, P < 0.01). No correlation was found between the fasting plasma triglyceride level and either of the plasma post‐heparin lipolytic activities. Multivariate analysis revealed that 95% of the variance in triglyceride levels could be explained by the apolipoprotein B fractional synthetic rate and the chylomicron remnant clearance rate. The strong correlation between chylomicron remnant clearance, a measure of exogenous lipid metabolism, and fasting (hence, endogenous) plasma triglyceride levels suggests that remnants of chylomicrons and very low density lipoproteins share some common components of the removal process.

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