Separation of Lichen Metabolites, Pyridine Derivatives, and Pyrimidine Bases Using Microbore, Reversed-phase LC

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Abstract
The application of microbore, reversed-phase columns in the separation of three different solute classes, each using different operating conditions, is described. Lichen metabolites were resolved in the ion-suppression mode. A large number of pyridine derivatives was separated in conjunction with the recently reported mobile-phase additive bis(2,2,6,6-tetramethyiheptane-3,5-dionato)nickel(II). Finally, a separation of pyrimidine bases was achieved using additive-saturated stationary phases. These separations illustrate the combined advantages of high mass sensitivity, low solvent consumption, and high efficiency available with microbore systems.