Improved Synthesis of 2-Amino-3-cyanopyridines in Solvent Free Conditions under Microwave Irradiation†
- 1 January 1998
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Chemical Research
- No. 6,p. 330-331
- https://doi.org/10.1039/a708521d
Abstract
A simple and efficient method is developed for the rapid synthesis of 2-amino-3-cyanopyridines 3–5 from arylidenemalanonitriles 1 and ketones 2 or 4 in presence of ammonium acetate without solvent/containing traces of solvent under microwave irradiation:reaction times are considerably reduced with improved yields as compared to those obtained under classical heating.Keywords
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