The early uptake of radioactive calcium by human lymphocytes treated with phytohaemagglutinin.

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  • 1 September 1971
    • journal article
    • Vol. 21  (3) , 509-16
Abstract
Phytohaemagglutinin (PHA) is presumed to react initially with receptors on the surface of lymphocytes and may cause permeability or other changes in the lymphocyte cell membrane. The uptake of radioactive calcium (45Ca) by normal human blood lymphocytes increased within 38 minutes of adding PHA, and there was little further increase in 45Ca uptake between 38 and 78 minutes. This effect of PHA was demonstrated at pH 7.2 and pH 7.5. There was no detectable uptake of 45Ca by human erythrocytes under the same conditions, with or without PHA. The observations are compatible with an early uptake of calcium when PHA initiates cell division, analogous to the role of calcium in muscle and secretory cells.

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