Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells.
Open Access
- 1 January 1976
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 143 (1) , 225-231
- https://doi.org/10.1084/jem.143.1.225
Abstract
A new animal model characterized by hereditary athymia and asplenia was used as a recipient of chronic myelogenous leukemic (CML) cells with the Philadelphia (Ph1+) chromosome. Transplanted CML cells form solid vascularized tumors containing cells similar to those seen in the patient in a long-term culture. Cells taken from the tumors were nearly triploid, retained all human chromosome markers, and had the same antigenic determinants(s) as cells in culture.Keywords
This publication has 11 references indexed in Scilit:
- Infleuence of a neonatal spleen transplant on hematopoiesis of hereditarily asplenic mice.1975
- Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.1975
- Alteration of Bone Marrow-Thymus Cell Synergism in Hereditary Asplenic and Adult Splenectomized MiceExperimental Biology and Medicine, 1975
- Immune competence of hereditarily asplenic mice.1974
- The Influence of Fibrin Formation on the Transplantability of Murine Tumour Cells: Implications for the Mechanism of the Révész EffectBritish Journal of Cancer, 1974
- Athymic Development in the MouseDifferentiation, 1973
- Splenic determination of immunocompetence: Influence on other lymphoid organsCellular Immunology, 1971
- Immunoglobulin Synthesis in Hereditarily Spleenless MiceNature, 1969
- Applications of Iso-Immune Cytolysis Using Radiolabelled Target CellsNature, 1964
- Hereditary Absence of Spleen in the MouseNature, 1959