Neonatal alloimmune thrombocytopenia due to anti‐P1A1 (anti‐hpa‐1a): Importance of paternal and fetal platelet typing for assessment of fetal risk

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Abstract
Neonatal alloimmune thrombocytopenia (NAIT), which usually involves sensitization to P1A1 (HPA‐1a), may have devastating complications for the fetus. These may be prevented by antenatal treatment of severe cases with either maternally administered high‐dose gamma‐globulin and/or repeated intrauterine platelet transfusions. Determination of the paternal platelet phenotype is useful for counselling parents who have had one or more affected pregnancies. This report of an unaffected pregnancy in a woman with a history of previous pregnancies complicated by NAIT illustrates the role of paternal and fetal platelet phenotyping in managing existing pregnancies at risk of NAIT.