Serial Positron Emission Tomography Imaging of Changes in Amino Acid Metabolism in Low Grade Astrocytoma After Radio and Chemotherapy
- 1 January 1995
- journal article
- case report
- Published by Japan Neurosurgical Society in Neurologia medico-chirurgica
- Vol. 35 (11) , 808-812
- https://doi.org/10.2176/nmc.35.808
Abstract
A 37-year-old male with mixed glioma was treated with combined radio- and chemotherapy. The amino acid metabolism of the tumor site and normal brain was followed by positron emission tomography using [11C]methionine ([11C]Met). The accumulation of [11C]Met in the tumor decreased during therapy and slightly increased 7 months after completion of the therapy, but then decreased markedly. However, computed tomography revealed no notable changes. The contralateral gray matter also showed a gradual decrease of [11C]Met accumulation. These findings indicate that reduction of amino acid metabolism in the tumor continues after radiochemotherapy although neuroimaging reveals no further morphological changes. Such therapy also has long-term effects on normal brain tissue.Keywords
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