Novel Aromatic/Heterocyclic Sulfonamides and Their Metal Complexes as Inhibitors of Carbonic Anhydraseisozymes I, II and IV
- 1 January 1997
- journal article
- research article
- Published by Taylor & Francis in Journal of Enzyme Inhibition
- Vol. 12 (1) , 37-51
- https://doi.org/10.3109/14756369709027662
Abstract
Reaction of five aromatic/heterocyclic sulfonamides containing free amino, groups with 5-nitro-α-2-toluenesultone and diethyl pyrocarbonate, respectively, afforded novel inhibitors of the zinc enzyme carbonic anhydrase (CA). Zn(II) complexes of the new sulfonamides were prepared. Excellent inhibition of three CA isozymes (CA I, II and IV respectively) were observed with some of the new sulfonamides, but especially with their Zn(II) complexes. Structure-activity correlations in this series of inhibitors are discussed.Keywords
This publication has 40 references indexed in Scilit:
- CARBONIC ANHYDRASE INHIBITORS. Part 32. ISOZYME II INHIBITION WITH ORGANOPHOSPHORIC COMPOUNDS CONTAINING SUBSTITUTED SULFONAMIDO MOIETIESMain Group Metal Chemistry, 1995
- Evaluation of carbonic anhydrase isozymes in disorders involving osteopetrosis and/or renal tubular acidosisClinical Biochemistry, 1991
- 1,3,4-Thiadiazole- and Thiadiazolinesulfonamides as Carbonic Anhydrase Inhibitors. Synthesis and Structural StudiesJournal of the American Chemical Society, 1956
- Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors1Journal of the American Chemical Society, 1950
- The Preparation of Heterocyclic Sulfonamides1Journal of the American Chemical Society, 1950
- N4-Substituted SulfonamidesJournal of the American Chemical Society, 1944
- Substituted Sulfanilamides. II. N1- and N4-Sulfonyl DerivativesJournal of the American Chemical Society, 1940
- Sulfanilamide Compounds. III. N4-Heteroöyl Derivatives of N1-Substituted SulfanilamidesJournal of the American Chemical Society, 1940
- Substituted Sulfanilamides. I. N4-Acyl DerivativesJournal of the American Chemical Society, 1939
- Organic Compounds in Chemotherapy. I. Derivatives of SulfanilamideJournal of the American Chemical Society, 1939