Cardiovascular effect of "peritoneal dialysate-depressor-I", a short-active hypotensive phospholipid in dog peritoneal dialysate.

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Abstract
Cardiovascular action of peritoneal dialysate-depressor-I (PD.D-I), a short-acting hypotensive phospholipid occurring in dog peritoneal dialysate, was investigated. With an i.v. injection of PD.D-I into an anesthetized rat, a sharp fall of arterial blood pressure was observed and the effects were dose-dependent. The maximum hypotensive effect was .apprx. 60 mmHg and the minimum effective dose was .apprx. 35 .mu.g/kg. Neither tachyphylaxis nor sensitization was observed. Even in conscious rats PD.D-I elicited hypotensive responses, though the effect was much weaker than that produced in anesthetized rats. In spinal rats the hypotensive effects were observed. In the tests on rats reserpinized or pretreated with antimuscarinic, antihistaminic, .beta.-adrenergic-blocking and ganglionic-blocking agents, the depressor effect of PD.D-I was not affected. PD.D-I elicited hypotensive responses in anesthetized cats, rabbits and guinea pigs in the same degree as those in anesthetized rats. The relaxation of the peripheral blood vessels was observed in the test on perfused rabbit ear. The depressor factor showed no smooth muscle stimulating activity in isolated guinea pig ileum preparations. Judging from these findings, the hypotensive effect of PD.D-I is not ascribable to the central, sympathetic or parasympathetic nervous system but possibly to direct action on the peripheral vascular system.