Effect of (Asu1,7)-EEL calcitonin and its fragments on gastric acid secretion in rats.

Publisher Website
Google Scholar
Abstract
The effect of [Asu1,7]-eel calcitonin ([Asu1,7]-E-CT), an analog of natural eel calcitonin, and its fragments on gastric acid secretion was studied in pylorus-ligated rats. [Asu1,7]-E-CT markedly reduced the acid secretion with i.v. and i.m. doses of 3 Medical Research Council units (MRC U)/kg or 0.6 .mu.g/kg. This activity was comparable to that of salmon calcitonin and porcine calcitonin in equivalent hypocalcemic doses and was consistently evident during daily administrations for 10 days. Assay of 6 fragments of [Asu1,7]-E-CT showed that the C-terminal peptide consisting of 22 amino acids diminished the acid secretion but shorter peptides of the C-terminal fragment or the N-terminal fragments did not. The C-terminal peptide may play an important role in this action of [Asu1,7]-E-CT, and a peptide chain of over 18 amino acids is required.

This publication has 1 reference indexed in Scilit: