Sequence preferences in the binding to DNA of triostin A and TANDEM as reported by DNase I footprinting
- 29 October 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 176 (2) , 414-420
- https://doi.org/10.1016/0014-5793(84)81209-0
Abstract
Six or seven triostin-binding sites have been identified in a 160-base-pair DNA restriction fragment containing the tyr T promoter sequence. Each is centred round a CpG step, and the minimum binding site-size appears to be six base pairs. The sites are practically the same as those reported for echinomycin by DNase I digestion. Only two sites are protected by binding of TANDEM, the des-N-tetramethyl analogue of triostin A; they are centred around the sequences ATA or TAT.Keywords
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