Unique Chromatin Remodeling and Transcriptional Regulation in Spermatogenesis
Top Cited Papers
- 21 June 2002
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 296 (5576) , 2176-2178
- https://doi.org/10.1126/science.1070963
Abstract
Most of our knowledge of transcriptional regulation comes from studies in somatic cells. However, increasing evidence reveals that gene regulation mechanisms are different in haploid germ cells. A number of highly specialized strategies operate during spermatogenesis. These include a unique chromatin reorganization program and the use of distinct promoter elements and specific transcription factors. Deciphering the rules governing transcriptional control during spermatogenesis will provide valuable insights of biomedical importance.Keywords
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