Abstract
Investigations were made on the morphological and histochemical nature of the ellipsoid sheaths of two different types of spleens, sinusal and non‐sinusal, as found in the dog and cat respectively.Ellipsoid cells of dog and cat spleens respond similarly with Marshall's silver impregnation method as well as demonstrate activity for the hydrolytic enzyme, acid phosphatase. Both technics substantiate ellipsoid involvement in the reticuloendothelial system. Nonspecific esterase, another hydrolytic enzyme commonly found in phagocytic cells, was demonstrated in the cat ellipsoid cells but not in similar cells of the dog spleen indicating a basic difference in the physiological activity of the dog and cat ellipsoid cells.