Large Intracranial Aneurysm Producing Panhypopituitarism and Frontal Lobe Syndrome

Abstract
A 54-year-old female with an intracranial aneurysm (7.5 x 5 cm) producing sella turcica erosion, panhypopituitarism, frontal lobe syndrome and opthalmoplegia is presented. Extensive clinical and laboratory data with photographs and arteriograms, pre- and post-carotid artery ligation, are discussed. The patient''s electrolyte and endocrine status was evaluated revealing varied patterns of endocrine deficiencies and intracranial space occupying lesions. Stabilization was accomplished with strict hormonal therapy. Hypothalamicoadenohypophyseal relationships are implicated and discussed. The case represents: (1) the largest intact intracranial aneurysm reported; (2) the first example of panhypopituitarism and frontal lobe syndrome due to an intracranial aneurysm.

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