Factors Associated with Immunoglobulin G Subclass Polarization in Naturally Acquired Antibodies to Plasmodium falciparum Merozoite Surface Proteins: a Cross-Sectional Survey in Brazilian Amazonia

Open Access

1 July 2006

journal article
Published by American Society for Microbiology in Clinical and Vaccine Immunology

Vol. 13 (7) , 810-813
https://doi.org/10.1128/cvi.00095-06

Abstract

We investigated immunoglobulin G (IgG) subclass antibody responses to Plasmodium falciparum merozoite surface protein 1 (MSP-1) and MSP-2 in 112 malaria-exposed subjects in Brazil. IgG3 polarization was primarily epitope driven, being little affected by cumulative or current exposure to malaria and not affected by a subject's age and Fcγ receptor IIA genotype.

Keywords

This publication has 39 references indexed in Scilit:

Target Antigen, Age, and Duration of Antigen Exposure Independently Regulate Immunoglobulin G Subclass Switching in Malaria
Infection and Immunity, 2006
Influence of Carriage of Hemoglobin AS and the Fcγ Receptor IIa–R₁₃₁Allele on Levels of Immunoglobulin G2 Antibodies toPlasmodium falciparumMerozoite Antigens in Gabonese Children
The Journal of Infectious Diseases, 2005
Antigenic Diversity and Immune Evasion by Malaria Parasites
Clinical and Vaccine Immunology, 2004
Differential Recognition of Plasmodium falciparum Merozoite Surface Protein 2 Variants by Antibodies from Malaria Patients in Brazil
Clinical and Vaccine Immunology, 2003
Repeat Sequences in Block 2 ofPlasmodium falciparumMerozoite Surface Protein 1 Are Targets of Antibodies Associated with Protection from Malaria
Infection and Immunity, 2003
Regulation of Antigen-Specific Immunoglobulin G Subclasses in Response to Conserved and PolymorphicPlasmodium falciparumAntigens in an In Vitro Model
Infection and Immunity, 2002
Expression and antigenicity of Plasmodium falciparum major merozoite surface protein (MSP119) variants secreted from Saccharomyces cerevisiae
Molecular and Biochemical Parasitology, 1994
Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes.
The Journal of Experimental Medicine, 1990
Killing of Plasmodium falciparum by cytokine activated effector cells (neutrophils and macrophages)
Immunology Letters, 1990
Opsonization as an effector mechanism in human protection against asexual blood stages of Plasmodium falciparum: Functional role of IgG subclasses
Research in Immunology, 1990